By Richard Gorlin, George D. Dangas, Pavlos K. Toutouzas, M.M. Konstadoulakis
In the period of immediate international verbal exchange, drugs is a global self-discipline characterised through a variety of sufferer referral structures, world-wide dialogue of scientific and learn findings, and an explosion within the clinical literature. might be no box has stepped forward greater than cardiology long ago few years.
Contemporary thoughts in Cardiology has been conceived as a complement to the vintage cardiology textbooks for using practising physicians, cardiologists-in-training, scientific scholars, and learn investigators. This quantity specializes in institutions among refinements within the figuring out of affliction and scientific purposes. the cloth is gifted in a fashion that limns the newest advances and focuses considering in the direction of destiny advancements in cardiology.
The Editors have assembled a revered overseas panel of participants in order that each one bankruptcy is authored by means of a widely known professional in his or her box. each try used to be made to prevent the fragmentation which frequently characterizes the digest method. as the consistent circulation of knowledge makes it approximately most unlikely to build a well timed publication on advances in cardiology, the chapters during this quantity describe the present ideas in cardiology and their underlying purpose, instead of trying a complete evaluation of the latest papers in every one discipline.
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Additional info for Contemporary Concepts in Cardiology: Pathophysiology and Clinical Management
VLDL CE PL VLDL, triglycerides are broken down to free fatty acids for tissue uptake, particularly by muscle and fat. Cholesterol is delivered to tissues and may be important to the function of steroid-synthesizing organs, particularly the adrenal glands and Iiver. 3,4 Chylomicrons and chylomicron remnants Chylomicrons are the largest lipoproteins and in the nonfasting state are the major triglyceride-carrying lipoproteins (Figure 3. 1). After a meal, triglycerides and cholesterol are packaged into chylomicrons by the intestinal mucosal cell and carried via the mesenteric lymphatics and thoracic duct into the blood stream.
Chylomicrons possess a unique and defining apolipoprotein, apo B-48, that is present only on chylomicrons and their remnants, and remains with the chylomicron throughout its metabolism. Apo B-48 is identical to the amino-terminal half of apo B-IOO, the apolipoprotein of low density lipoprotein (LDL) but ends at amino acid 2,152. 5 Apo B-48 is about one half the size of apo B-100 and, lacking the carboxy-terminal portion of apo B-100, has no LDL receptor-binding site. After mixing with plasma, chylomicrons interact extensively with high density lipoprotein (HDL) and exchange their apo A's for the C and E apolipoproteins in HDL.
Circulation, 1993: 87:1781. 55. Scandinavian Simvastatin Survival Study Group. Randomized trial of cholesterol lowering in 4444 patients with coronary artery disease: the Scandinavian Simvastatin Survival Study (4S). Lancet, 1994: 344:1383. 56. Pfeffer MA, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargment Trial. N Eng J Med, 1992: 327:669. 57. The SOLVD investigators.
Contemporary Concepts in Cardiology: Pathophysiology and Clinical Management by Richard Gorlin, George D. Dangas, Pavlos K. Toutouzas, M.M. Konstadoulakis