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Clinical Applications of Mass Spectrometry in Drug Analysis: - download pdf or read online

By Uttam Garg

ISBN-10: 1493932519

ISBN-13: 9781493932511

ISBN-10: 1493932527

ISBN-13: 9781493932528

This quantity describes tools and protocols for a few medicinal drugs and pollution in a stepwise demeanour. Chapters within the e-book disguise a wide range of subject matters reminiscent of: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitation of overall Buprenorphine and Norbuprenorphine in Meconium; quantitation or Carisoprodol and Meprobamate in Urine; and quantitation of Tricyclic Antidepressants in Serum. every one bankruptcy incorporates a short creation to the subject, scientific software of the analyte(s), and invaluable notes to assist laboratorians simply reproduce the protocols mentioned. Written within the hugely profitable Methods in Molecular Biology series layout, chapters comprise introductions to their respective subject matters, lists of the required fabrics and reagents, step by step, conveniently reproducible laboratory protocols, and pointers on troubleshooting and averting identified pitfalls.

Authoritative and thorough, Clinical purposes of Mass Spectrometry in Drug research: equipment and Protocols, is a very good source for laboratorians who're already utilizing mass spectrometry or contemplating introducing this expertise to their laboratories.

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Extra resources for Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols

Sample text

Tandem mass spectrometry: Mass spectrometric detection was performed using an Applied Biosystems API 4000 triple quadropole mass spectrometer equipped with an electrospray 34 Dean C. Carlow et al. 0 300 5 95 Table 4 Analyte precursor and product ions (m/z) Analyte Precursor ion 1° Product ion 2° Product ion CE (V) LVA 171 126 154 17 ZNS 213 132 77 22 LTG 256 211 145 38 MHD 255 194 237 25 TOP 340 264 282 25 Clonazepam-D4 320 274 N/A 35 Optimized m/z may change based on instrument and tuning parameters ionization (ESI) source operating in a positive ion mode.

5. Centrifuge for ~10 min at ~18,000 × g (see Note 3). 6. Transfer the contents of each tube (from steps 2 to 5) to an autosampler vial and cap. 7. Analyze on LC-MS/MS. 2 Instrument Operating Conditions 1. Table 2 summarizes typical LC conditions. 2. Table 3 summarizes typical MS conditions. 3. Table 4 summarizes typical MRM conditions. Each instrument should be individually optimized for best method performance. 3 Data Analysis 1. Representative MRM chromatograms of each antipsychotic and internal standard in plasma are shown in Fig.

Prepare low (50 ng/mL), medium (350 ng/mL) and high (650 ng/mL) controls according to Table 2 by spiking drugfree human plasma with a different set of dabigatran, rivaroxaban, apixaban, and warfarin stock solutions. Transfer aliquots to microcentrifuge tubes for storage at −80 °C. The controls are stable for 1 year. 24 Jaime H. Noguez and James C. 5 Supplies and Equipment 1. 8 μm particle size, 600 bar (Agilent Technologies, Santa Clara, CA). 2. , Milford, MA). 3. , Milford, MA). 1 Stepwise Procedure 1.

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Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols by Uttam Garg


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