By Dan M. Roden
This accomplished and concise presentation of genetic elements in heart problems and their reaction to remedy consolidates wisdom of this high-interest and rising subject. masking large components of latest genomic drugs and particular cardiovascular ailments, this ebook is a needs to for someone looking to greater comprehend this quickly constructing box.
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Additional info for Cardiovascular Genetics and Genomics (American Heart Association Clinical Series)
Within a population, patients with the same diagnosis can be divided into two groups: (1) patients with favorable response and (2) ethnic patients with no response or toxicity. The latter group requires a treatment adjustment with an alternative drug or dose. ) of all drugs are metabolized by this enzyme. Mutations in the CYP2D6 locus result in a non-encoded enzyme, a deficient enzyme, or an enzyme with increased activity . This leads to four activity levels (or phenotypes): poor metabolizers (PMs); intermediate metabolizers (IMs); extensive metabolizers (EMs); and ultrarapid metabolizers (UMs) [20,21].
The family-based study design is flexible in which family members are targeted for ascertainment, albeit with differing levels of power to detect either linkage or association between the trait of interest and the risk-conferring locus. Ascertainment of study subjects for a family-based study design can be subdivided into three basic categories: (1) nuclear, (2) extended, and (3) pair. The basic unit of ascertainment for the nuclear family pedigree is the mother, the father, and their offspring (who represent independent meiotic events).
Science 2007; 316: 1491–1493. 16 Part I Principles 11 Saxena R, Voight BF, Lyssenko V et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 3b16: 1331–1336. 12 Scott LJ, Mohlke KL, Bonnycastle LL et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316: 1341–1345. 13 Zeggini E, Weedon MN, Lindgren CM et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Cardiovascular Genetics and Genomics (American Heart Association Clinical Series) by Dan M. Roden