Press "Enter" to skip to content

Download e-book for kindle: Cardiac Safety of Noncardiac Drugs: Practical Guidelines for by Joel Morganroth, Ihor Gussak

By Joel Morganroth, Ihor Gussak

ISBN-10: 158829515X

ISBN-13: 9781588295156

Simple and medical researchers from and academia element the preclinical, scientific, and regulatory ideas at the moment used to evaluate the cardiac safeguard of latest medicines. The authors clarify the parameters of cardiac defense in any respect phases of medical examine and drug improvement, together with either the preclinical and pharmacogenomic features quite often and the medical methodologies and technical features for investigational medications according to cardiac repolarization, as outlined through the period of the QTc period. extra chapters comprehensively assessment the applying of electrocardiography in medical examine, the basics of ECG interpretation in medical trials, the statistical research plans for ECG facts bought in formal medical trials, and the sensible interpretation of the ECG effects. Highlights contain sensible counsel on the best way to behavior an intensive ECG Trial in New Drug improvement, how one can use new ECG and internet established know-how in medical examine, and the way to persist with the hot FDA requisites for ECG submissions.

Show description

Read Online or Download Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development PDF

Best cardiovascular books

Download e-book for iPad: Heat Shock Proteins in Myocardial Protection by Rakesh C. Kukreja

This publication describes the position of warmth surprise proteins myocardial ischemia. It addresses the function of warmth surprise proteins in ischemia-reperfusion, in myocardial defense, within the functionality of protein kinase C (PKC) and potassium channels, in tumor necrosis issue functionality, and in antisense.

Download e-book for iPad: Physiology at a Glance by Jeremy P. T. Ward, Roger W. A. Linden

This revised and up-to-date version of body structure at a look gains transparent and concise illustrations, memorable info tables, and easy-to-read textual content, to supply an intensive creation to body structure that integrates seamlessly with the scientific university curriculum. body structure at a look breaks the subject down into its middle elements, facing buildings of the physique from mobile point to composite structures.

New PDF release: Kaplan’s Clinical Hypertension

This best-selling scientific reference through a world-renowned authority on high blood pressure used to be indexed because the no 1 reference booklet for high blood pressure by means of the yank Society for high blood pressure in 2006. Dr. Kaplan integrates the newest uncomplicated technology findings and medical trial info and offers up to date, useful, evidence-based strategies for remedy and prevention of all varieties of high blood pressure.

Additional info for Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development

Example text

3. Molecular compositions of functional cardiac Nav, Cav, and Kvchannels. Upper panel: the four domains of Nav (and Cav) F subunit form monomeric Nav (and Cav) channels, whereas four Kv or Kir F subunits combine to form tetrameric Kv and Kir channels. Lower panel: schematic illustrating functional cardiac Nav, Cav, and Kv channels, composed of the pore-forming F subunits and a variety of accessory subunits. co-expression (127). In co-expression studies, all four CavG subunits associate with CavF1 subunits and modify the amplitudes, as well as the time- and voltage-dependent properties, of the currents (128–133).

J Gen Physiol 1992; 100:1041–1067. Chapter 2 / Ion Channels Underlying Repolarization 31 61. Yue L, Feng J, Li GR, Nattel S. Characterization of an ultra rapid delayed rectifier potassium channel involved in canine atrial repolarizzation. J Physiol 1996;496:647–662. 62. Wang Z, Fermini B, Nattel S. Sustained depolarization-induced outward current in human atrial myocytes. 5 cloned channel currents. Circ Res 1993; 73:1061–1076. 63. Wang Z, Fermini B, Nattel S. Delayed rectifier outward current and repolarization in human atrial myocytes.

Delayed-rectifier potassium channel activity in isolated membrane patches of guinea pig ventricular myocytes. Am J Physiol 1991; 260: H1390–H1393. 46. Anumonwo JM, Freeman LC, Kwok WM, Kass RS. Delayed rectification in single cells isolated from guinea pig sinoatrial node. Am J Physiol 1992; 262:H921– H925. 47. Follmer CH, Colatsky TJ. Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes. Circulation 1990; 82:289–293. 48. Wang Z, Fermini B, Nattel S.

Download PDF sample

Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development by Joel Morganroth, Ihor Gussak


by Christopher
4.5

Rated 4.55 of 5 – based on 47 votes