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Download e-book for kindle: Cardiac Safety of Noncardiac Drugs: Practical Guidelines for by Joel Morganroth, Ihor Gussak

By Joel Morganroth, Ihor Gussak

ISBN-10: 158829515X

ISBN-13: 9781588295156

Simple and medical researchers from and academia element the preclinical, scientific, and regulatory ideas at the moment used to evaluate the cardiac safeguard of latest medicines. The authors clarify the parameters of cardiac defense in any respect phases of medical examine and drug improvement, together with either the preclinical and pharmacogenomic features quite often and the medical methodologies and technical features for investigational medications according to cardiac repolarization, as outlined through the period of the QTc period. extra chapters comprehensively assessment the applying of electrocardiography in medical examine, the basics of ECG interpretation in medical trials, the statistical research plans for ECG facts bought in formal medical trials, and the sensible interpretation of the ECG effects. Highlights contain sensible counsel on the best way to behavior an intensive ECG Trial in New Drug improvement, how one can use new ECG and internet established know-how in medical examine, and the way to persist with the hot FDA requisites for ECG submissions.

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Additional info for Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development

Example text

3. Molecular compositions of functional cardiac Nav, Cav, and Kvchannels. Upper panel: the four domains of Nav (and Cav) F subunit form monomeric Nav (and Cav) channels, whereas four Kv or Kir F subunits combine to form tetrameric Kv and Kir channels. Lower panel: schematic illustrating functional cardiac Nav, Cav, and Kv channels, composed of the pore-forming F subunits and a variety of accessory subunits. co-expression (127). In co-expression studies, all four CavG subunits associate with CavF1 subunits and modify the amplitudes, as well as the time- and voltage-dependent properties, of the currents (128–133).

J Gen Physiol 1992; 100:1041–1067. Chapter 2 / Ion Channels Underlying Repolarization 31 61. Yue L, Feng J, Li GR, Nattel S. Characterization of an ultra rapid delayed rectifier potassium channel involved in canine atrial repolarizzation. J Physiol 1996;496:647–662. 62. Wang Z, Fermini B, Nattel S. Sustained depolarization-induced outward current in human atrial myocytes. 5 cloned channel currents. Circ Res 1993; 73:1061–1076. 63. Wang Z, Fermini B, Nattel S. Delayed rectifier outward current and repolarization in human atrial myocytes.

Delayed-rectifier potassium channel activity in isolated membrane patches of guinea pig ventricular myocytes. Am J Physiol 1991; 260: H1390–H1393. 46. Anumonwo JM, Freeman LC, Kwok WM, Kass RS. Delayed rectification in single cells isolated from guinea pig sinoatrial node. Am J Physiol 1992; 262:H921– H925. 47. Follmer CH, Colatsky TJ. Block of delayed rectifier potassium current, IK, by flecainide and E-4031 in cat ventricular myocytes. Circulation 1990; 82:289–293. 48. Wang Z, Fermini B, Nattel S.

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Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development by Joel Morganroth, Ihor Gussak

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