By Haim Tal
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2005) A new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (LAB). J Bone Miner Res, 20(8), 1394-1402. , & Dupin, E. (2004). Neural crest cell plasticity and its limits. Development, 131(19), 4637-4650. , & Carpenter, M. (2001). Human embryonic stem cells: culture, differentiation, and genetic modification for regenerative medicine applications. Cancer J, 7 Suppl 2, S83-S93. , & Longaker, M. (2011). Concise review: adipose-derived stromal cells for skeletal regenerative medicine.
2004). Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro. Calcif Tissue Int, 74(5), 458-468. Meinel, L; Karageorgiou, V; Fajardo, R; Snyder, B; Shinde-Patil, V; Zichner, L; Kaplan, D; Langer, R; Vunjak-Novakovic, G. (2004a). Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Ann Biomed Eng, 32(1), 112-122. , Kaplan, D. (2004b). Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds.
2. Treatment of bone defects The reconstruction of large bone defects is an important clinical problem and none of the approaches thus far have proved completely effective. Since there are major limitations when treating ”problematic” bone tissue defects according to standard protocols, there is a great need for the development of new approaches for reparative osteogenesis. There are a number of clinical indications, such as non-unions, benign bone lesions, parodontal bone lesions, traumatic injuries, which could benefit from advances made during the past decade in bone cell therapies and tissue engineering.
Bone Regeneration by Haim Tal