By P. Serra
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Fig. 23. 25 μg/ml to 17 μg/ml. 4 Lactic acid detection Lactic acid can also be detected with ZnO nanorod-gated AlGaN/GaN HEMTs. Interest in developing improved methods for detecting lactate acid has been increasing due to its importance in areas such as clinical diagnostics, sports medicine, and food analysis. An accurate measurement of the concentration of lactate acid in blood is critical to patients that are in intensive care or undergoing surgical operations as abnormal concentrations may lead to shock, metabolic disorder, respiratory insufficiency, and heart failure.
This stability is important to exclude possible noise from the mechanical change of the buffer solution. By sharp contrast, the current change showed a rapid response in less than 20 seconds when the sensor was dipped into the 100 ml of 10 mM glucose solution using DI water as the solvent. This sudden drain current increase indicated that GOx immediately reacted with glucose and oxygen was produced as a by-production of this reaction. However, the drain current gradually decreased. This was due to the oxygen produced in the GOx-glucose interaction reacting with water and changing the pH value adjacent the gate area.
Smaller antigens carry less charges, thus provide less effect on the drain current of the HEMT sensor. Based on the promising biomarker and device data, we have recently used HEMTs for detecting a biomarker UCH-L1 (BA0127) antigen involved in Traumatic Injury Molecule. The gate region was functionalized with a specific antibody to traumatic brain injury antigen. The HEMT current showed a decrease as a function of TBI antigen concentration in PBS buffer (Figure 30). 9, 80, and 188 µg/ml of BA0127 (UCH-L1) in PBS buffer.
Biosensors for Health, Environment and Biosecurity by P. Serra